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GAZA/TEL AVIV/ABOARD AIR FORCE ONE: Israel and Gaza militants vowed to keep fighting after US President Joe Biden urged Prime Minister Benjamin Netanyahu to seek a "de-escalation" on Wednesday on the path to a ceasefire in the 10-day conflict.

An Egyptian security source said the two sides had agreed in principle to a ceasefire after help from mediators, although details were still being negotiated in secret amid public denials of a deal to prevent it from collapsing.

Palestinian health officials said that since fighting began on May 10, 228 people had been killed in aerial bombardments that have worsened an already dire humanitarian situation in Gaza.

Israeli authorities put the death toll at 12 in Israel, where repeated rocket attacks have caused panic and sent people rushing into shelters.

Regional and US-led diplomatic efforts to secure a ceasefire have intensified but so far failed. Cross-border fire continued unabated after Biden's latest call for calm, and Gaza's rulers Hamas and other militants vowed defiance. Netanyahu has repeatedly hailed what he has described as support from the United States, Israel's main ally, for a right to “self-defence in battling attacks from Gaza”, home to two million Palestinians. But Biden put the Israeli leader on notice in a telephone call that it was time to lower the intensity of the conflict.

"The two leaders had a detailed discussion on the state of events in Gaza, Israel's progress in degrading the capabilities of Hamas and other terrorist elements, and ongoing diplomatic efforts by regional governments and the United States," White House spokeswoman Karine Jean-Pierre told reporters.

"The president conveyed to the prime minister that he expected a significant de-escalation today on the path to a ceasefire."

'QUIET AND SECURITY'

In a statement released soon after her comments, Netanyahu said: "I am determined to continue this operation until its objective is achieved - to restore quiet and security to you, the citizens of Israel."

Netanyahu had earlier told a meeting with foreign envoys to Israel that "it is not possible to set a timeframe" for the operations, Israeli media reported.

In response to Biden's de-escalation call, Hamas spokesman Hazem Qassam said those who sought to restore calm must "compel Israel to end its aggression in Jerusalem and its bombardment of Gaza".

Once that happened, Qassam said, "there can be room to talk about arrangements to restore calm".

The leader of Islamic Jihad, another Gaza militant group, said political talks "remain at a standstill".

"The only path towards freedom (is) to protect Jerusalem and people," said Islamic Jihad chief Ziad Al-Nakhala.

With Gaza rocket fire continuing into Wednesday night, a 72-year-old man was moderately injured when a rocket struck his house in the southern Israeli city of Sderot, medics said.

In Gaza, the sounds of explosions roared at nightfall with heavy bombardments reported in the enclave's centre and south.

Hamas began firing rockets on May 10 in retaliation for what it said were Israeli rights abuses against Palestinians in Jerusalem during the Muslim holy month of Ramadan.

In a 25-minute attack overnight into Wednesday, Israel bombarded targets including what its military said were tunnels in southern Gaza used by Hamas.

Some 50 rockets were fired from the enclave, the Israeli military said, with sirens sounding in the coastal city of Ashdod, south of Tel Aviv, and other areas.

Around 4,000 rockets have been fired from Gaza since May 10, most of which have been intercepted by missile defences, the Israeli military said. Some 600 fell in Gaza, it said.

CRATERS AND RUBBLE

Nearly 450 buildings in densely populated Gaza have been destroyed or badly damaged, including six hospitals and nine primary-care health centres, and more than 52,000 Palestinians have been displaced, the UN humanitarian agency said.

"Whoever wants to learn about the humanity of the (Israelis) should come to the Gaza Strip and look at the houses that got destroyed on top of those who lived in them," said university lecturer Ahmed al-Astal, standing by the rubble of his house in Khan Younis in southern Gaza. The hostilities are the most serious between Hamas and Israel in years, and, in a departure from previous Gaza conflicts, have helped fuel street violence in Israeli cities between Jews and Arabs.

The conflict has also spilled over to the Israel-Lebanon frontier and stoked violence in the occupied West Bank.

Four rockets were launched towards Israel from Lebanon on Wednesday, the third such incident since the Gaza conflict began, the military said. There was no claim of responsibility.

In the West Bank, Israeli troops shot dead a Palestinian woman who the military claimed had fired a rifle at troops and civilians. At least 21 Palestinians have been killed in clashes with Israeli troops or other incidents in the West Bank since May 10, Palestinian officials said.

Gaza medical officials say the Palestinian death toll includes 65 children, and that more than 1,600 people have been wounded since the fighting began. Israeli authorities say the death toll in Israel includes two children.

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